Dermovate

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What is Dermovate

Dermovate is a very potent steroid containing the active ingredient clobetasol propionate for the short-term treatment only of severe resistant inflammatory skin disorders such as psoriasis unresponsive to less potent corticosteroids. It belongs to the group of medicines for application to the skin called topical corticosteroids which should not be confused with anabolic steroid tablets or injections which can be misused by some athletes. Topical corticosteroids have been shown to reduce the itching, redness and inflammation of certain skin problems.

How does it work?

The active ingredient in Dermovate is formulated in several vehicles to aid its use on the skin. The ointment contains a moisturising base that provides a layer of oil on the surface of the skin, helping to prevent water from evaporating from the skin surface. The Cream is intended for moist skin conditions and there is a liquid scalp lotion.

Topical Corticosteroids suppress the inflammatory reaction during use; they are not curative and on discontinuation a rebound exacerbation of the condition may occur. They are generally used to relieve symptoms and suppress signs of the disorder when other measures such as emollients are ineffective.

Topical corticosteroids are often prescribed as first-line treatment because they are so easy to use.

Who can get it?

Available on prescription as a lotion, cream or ointment suitable for adults and children over 1 year old. Scalp lotion suitable for adults and children over 2 years old.

How is it used?

Cream and ointment
Apply sparingly once or twice daily for max. four weeks, then review.
Scalp treatment
Unscrew the cap on the bottle and place the nozzle on the part of the scalp that needs treating
2. Gently squeeze the bottle until the area to be treated is completely covered with a thin layer of liquid. You can gently rub it into the scalp if you wish
3. Your scalp will feel cool until the liquid has dried off. The active ingredient is then left on your scalp
4. As soon as the scalp problem looks better, use once a day or less
For a child:
It should not be used in children under one year of age.
Never use more than is needed to cover the scalp condition.
Do not use for a long time (nearly every day for weeks or months).
Do not cover with an airtight dressing.

What are the side effects?

As with other topical corticosteroids, prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. In infants, the napkin may act as an occlusive dressing. Provided the weekly dosage is less than 50g in adults, any suppression of the HPA axis is likely to be transient with a rapid return to normal values once the short course of steroid therapy has ceased. The same applies to children given proportionate dosage. Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes, such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or when skin folds are involved. There are reports of pigmentation changes and hypertrichosis with topical steroids. In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease (see Special warnings and special precautions for use).

Dermovate is usually well tolerated, but if signs of hypersensitivity appear, application should be stopped immediately.
Exacerbation of symptoms may occur.

Manufactured by

Dermovate is manufactured in the UK by GlaxoSmithKline.