Researchers in Australia have identified a gene called IKBKB that plays a key role in this disease. This scientific discovery has made an exciting breakthrough in understanding psoriasis.
In people with psoriasis, the immune system is overactive, leading to inflammation. The IKBKB gene can have mutations, which disrupt the normal function of special immune cells known as regulatory T cells. These cells usually help keep the immune response in check, but when they are affected by the gene mutation, they can contribute to inflammation and the development of skin issues associated with psoriasis and psoriatic arthritis.
Interestingly, having just one copy of the mutated gene can lead to skin symptoms, while two copies can result in psoriatic arthritis.
This discovery is a significant step forward in psoriasis research and could change how we treat the disease. By identifying which individuals with psoriasis are at risk of developing arthritis, doctors can provide early treatment, potentially preventing severe complications.
Moreover, there’s hope that with advancements in genetic technology, we may one day be able to “edit” the faulty gene to restore its normal function. While this is still a future possibility, it opens up exciting avenues for treatment and improved quality of life for those affected by psoriasis.
Reference
Cardinez C, Hao Y, Kwong K et al. IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model. Nature Communications, 2024; 15 (1) DOI: 10.1038/s41467-024-45870-3